CRYOcheck™ Clot C is a clot-based assay intended for the quantitative determination of protein C activity in citrated human plasma. CRYOcheck Clot C functions by direct activation of protein C in the patient sample using a protein C activator. The common pathway of coagulation is initiated with Russell's viper venom (RVV-X) reagent to convert factor X to Xa, bypassing all factors above the common pathway.
- Frozen format eliminates reconstitution errors
- Unaffected by factor VIII:C activity levels up to 600%
- Unaffected by samples from patients heterozygous for the factor VLeiden mutation
- Interference by lupus anticoagulants has not been observed
- Up to 300 tests per kit when using 3.0 mL format
CRYOcheck Clot C must be used with C & S Diluent, available separately from Precision BioLogic.